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Black Box Warnings
For BBWs and precautions for other drugs please visit this website:
Arixtra / Lovenox -
Spinal/Epidural hematomas: Patients anticoagulated with low molecular weight heparins (LMWHs) or fondaparinux are at risk of developing an epidural or spinal hematoma that can result in long-term or permanent paralysis when neuraxial anesthesia or spinal puncture is employed.
Frequently monitor patients for signs and symptoms of neurological impairment. If neurologic compromise is noted, urgent treatment is necessary.
Warfarin can cause major or fatal bleeding and is more likely to occur during the starting period and with a higher dose. Regular monitoring of INR should be performed on all treated patients and careful dose adjustment to desired INR. Consider employing the pharmacist warfarin dosing service for assistance.
Fentanyl Transdermal Patches -
Fentanyl transdermal systems contain a high concentration of fentanyl which has a high potential for abuse and an associated risk of fatal overdose caused by respiratory depression. Only use fentanyl transdermal system in patients who are opioid tolerant. Patients who are considered opioid tolerant are those who have been taking, for a week or longer, morphine 60 mg/day or more, or oral oxycodone 30 mg/day or more, or oral hydromorphone 8 mg/day or more, or an equianalgesic dose of another opioid.
Fentanyl transdermal is
in patients who are not opioid tolerant, in the management of acute or mild pain, in the management of acute or postoperative pain or intermittent pain responsive to as needed or non-opioid therapy, or in doses exceeding 25mcg/h at the initiation or opioid therapy. Peak fentanyl levels occur between 24 and 72 hours of treatment. Note that serious or life-threatening hypoventilation may occur, even in opioid-tolerant patients, during the initial application period.
- Furosemide is a potent diuretic and given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Careful supervision is required and dosing must be adjusted to individual patients’ needs.
- Astramorph PF, Infumorph, Duramorph: Because of the risk of severe adverse effects when the epidural or intrathecal route of administration is employed, patients must be observed in a fully equipped and staffed environment for at least 24 hours after the initial dose.
- Patients treated with infliximab are at increased risk for infections, including progression to serious infections leading to death. These have included bacterial sepsis, tuberculosis (TB), and invasive fungal, and other opportunistic infections. Evaluate patient for TB risk factors and test for latent TB prior to initiating and during therapy.
- Do not use promethazine in children younger than 2 years of age because of the potential for fatal respiratory depression. Use caution when administering promethazine to children 2 years of age or older by using the lowest effective dose and avoiding concomitant administration of other drugs with respiratory depressant effects. For all age groups, IM administration is preferred and IV administration is discouraged. IV administration should be at a concentration not to exceed 25 mg/mL and at a rate no greater than 25 mg/min. Avoid subcutaneous and intra-arterial injection because tissue necrosis and gangrene can result as well as with extravasated IV injections. Amputations have resulted.
Epoetin alfa (Epogen)
- Renal failure: Patients experienced greater risks for death and serious CV events when administered erythropoiesis-stimulating agents (ESAs) to target higher vs. lower hemoglobin levels. Individualize dosing to achieve and maintain hemoglobin levels within the range of 10 to 12 g/dL.
Cancer: ESAs shortened overall survival and/or increased the risk of tumor progression or recurrence in some clinical studies in patients with breast, non–small cell lung, head and neck, lymphoid, and cervical cancers. To decrease these risks use the lowest dose needed to avoid red blood cell transfusions. Use ESAs only for treatment of anemia caused by concomitant myelosuppressive chemotherapy. Discontinue following the completion of a chemotherapy course.
Perisurgery: Epoetin alfa increased the rate of deep venous thromboses in patients not receiving prophylactic anticoagulation. Consider deep venous thrombosis prophylaxis.
Ketorolac (inject and oral)
- Ketorolac is indicated for the short-term (up to 5 days) management of moderately severe acute pain that requires analgesia at the opioid level in adults. It is not indicated for minor or chronic painful conditions. The resulting NSAID-related adverse reactions can be serious in certain patients for whom ketorolac is indicated, especially when the drug is used inappropriately.
in patients with renal impairment or at risk for renal failure due to volume depletion.
as prophylactic analgesic before any major surgery and is
intra-operatively when hemostasis is critical due to the increased risk of bleeding.
Special populations: For patients >= 65 years of age, for patients less than 50 kg (110 lbs) of body weight or for patients with moderately elevated serum creatinine the dose should be adjusted to not exceed 60mg/24hrs.
Haloperidol and other anti-psychotics (typical and atypical)
- An increased incidence of cerebro-vascular adverse events (including fatalities) has been reported in elderly patients with dementia-related psychosis. These drugs are not approved for this indication. When haloperidol is used to treat delirium, continuous EKG monitoring with specific attention to a developing QTc interval prolongation is recommended.
Marshall Medical Center 1100 Marshall Way. Placerville, CA 95667
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